THE LXR-IDOL AXIS DEFINES A CLATHRIN-, CAVEOLAE-, AND DYNAMIN-INDEPENDENT ENDOCYTIC ROUTE FOR LDLR INTERNALIZATION AND LYSOSOMAL DEGRADATION

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR).Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane.Activation of the sterol-sensing nuclear receptors liver X receptors (LXRs) enhances degradation o

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A mummy in Venice: preliminary report about a work in progress

Mummies are the most interesting discovery from ancient Egypt, and like the hieroglyphs, they have Carrying Case become a symbol of the civilization of the pharaohs.Interest grows even stronger when science and technology allow us to learn about what the ancient Egyptians carefully embalmed and prepared for the afterlife.For archaeologists and cons

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